Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives.
نویسندگان
چکیده
The reagent system of I2/K2CO3 could efficiently promote the oxazole synthesis from α-bromoketones and benzylamine derivatives in DMF. This method was not only suitable for 2,5-diaryl oxazole synthesis but also for 2,4,5-trisubstituted oxazole and 5-alkyl/alkenyl oxazole synthesis. Furthermore, this method was successfully applied to a one-step synthesis of a natural product halfordinol in 62% yield.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 41 شماره
صفحات -
تاریخ انتشار 2013